Assessing the reliability of ChatGPT in cytogenetic reporting and interpretation: implications for clinical use.

Journal: Molecular cytogenetics
Published Date: Jul 18, 2025

Abstract

This study evaluates the accuracy of ChatGPT in generating chromosomal representations (formulas) based on ISCN rules in clinical cytogenetics. While ChatGPT generated correct answers for simple cases, it frequently failed in complex cases. These findings highlight the limitations of current AI tools in accurate clinical cytogenetic reporting, reinforcing the vital role of skilled clinical cytogeneticists for accurate interpretation and reporting.

Authors

  • Alain Chebly
    Center Jacques Loiselet for Medical Genetics and Genomics (CGGM), Faculty of Medicine, Saint Joseph University of Beirut (USJ), Beirut, Lebanon.
  • Lauren Veronese
    Université Clermont Auvergne, Unité de Recherche 7453 (CHELTER), Clermont-Ferrand, France.
  • Edith Chevret
    Bordeaux Institute of Oncology (BRIC), INSERM 1312, Université Bordeaux, 33000, Bordeaux, France.

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