Genetic and molecular underpinnings of the link between rheumatoid arthritis and myasthenia gravis: Insights from GWAS and transcriptomic analyses.

Journal: Clinical rheumatology
Published Date: Jul 19, 2025

Abstract

BACKGROUND: Although studies have shown that patients with rheumatoid arthritis (RA) are at a higher risk of developing myasthenia gravis (MG), the causal relationship and shared genetic basis between these two diseases have not been fully investigated. The purpose of this study is to uncover the potential bidirectional causality between RA and MG, and to explore their shared genetic factors and possible pathogenic mechanisms.

Authors

  • Jian Huang
    Center for Informational Biology, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu 611731, P. R. China.
  • Lu Wang
    Department of Laboratory, Akesu Center of Disease Control and Prevention, Akesu, China.
  • Xiaodong Hu
    Department of Pulmonary and Critical Care Medicine, Jiangyin Hospital of Traditional Chinese Medicine; Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Jiangyin, Jiangsu, 214400, China. huxido2000@sina.com.
  • Tianrui Wang
    Department of Orthopedics, The Affiliated Hospital of Qingdao University, Qingdao, China.
  • Yingze Zhang
    Division of Pulmonary, Allergy and Critical Care Medicine.

Keywords

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