Mucociliary Clearance Inspired Nanozyme-centric Hydrogel Composites for Integrated Bacterial Detection.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published Date:

Abstract

The rapid movement of populations has led to the transmission and infection of pathogens, imposing a significant burden on global healthcare systems and economies. Despite considerable progress, current strategies heavily rely on specialized instruments or complex processing of bacterial samples. Inspired by pulmonary cilia and the mucus on it, a nanozyme-centric hydrogel network, integrated into nanowires for comprehensive bacterial lysis and detection. Nanozymes serve as multifunctional initiators and crosslinkers for the hydrogel network, enabling a one-step gelation process that addresses the aggregation issues of nanozyme particles, and improving the sensitivity of colorimetric detection. By integrating the nanozyme-centric hydrogel with the rapid piercing capabilities of the nanowire arrays, an efficient platform is developed for the disinfection, lysis, and detection of various bacterial strains. Moreover, this detection platform is adaptable to flexible substrates and can be integrated with machine learning algorithms, promoting versatile home-based pathogen testing in resource-limited settings.

Authors

  • Zhaoling Tan
    School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, PR China.
  • Xuejiao Wang
    School of Literature and Journalism, Sanjiang University, Nanjing, Jiangsu 210012, China.
  • Zhaoyue Wang
    School of Electronics and Communication Engineering, Guangzhou University, Guangzhou 510006, China.
  • Jieke Jiang
    Medicine center for PanorOmic Sciences, University of Hong Kong, Pokfulam, Hong Kong SAR, P. R. China.
  • Xi Yao
    Department of Ophthalmology, Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou, China.

Keywords

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