Identification of biomarkers associated with pyroptosis and autophagy in facet joint osteoarthritis.

Journal: Clinical and experimental rheumatology
Published Date: Jul 21, 2025

Abstract

OBJECTIVES: Facet joint osteoarthritis (FJOA) is a degenerative spinal joint condition causing low back pain due to cartilage loss and joint damage. Although some studies have highlighted the importance of pyroptosis or autophagy in cartilage loss under FJOA, no report has identified the biomarkers between the two biological events. This direction demonstrates innovative potential and scientific value. The present study aimed to screen differentially expressed genes (DEGs) linked to pyroptosis and autophagy in FJOA and identify potential biomarkers for FJOA.

Authors

  • Xun Zhou
    Beidahuang Industry Group General Hospital, Harbin, China. Electronic address: zhouxun_harbin@126.com.
  • Chaochen Li
    Department of Orthopedics, Nantong City No. 1 People's Hospital and Second Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
  • Tianyi Wang
    College of Physical Education, Qiqihar University, Qiqihar 161000, China.
  • Qianqiu Li
    The First People's Hospital of Nantong, The Second Affiliated Hospital of Nantong University, Research Institute for Spine and Spinal Cord Disease of Nantong University, Nantong, Jiangsu, China.
  • Guanhua Xu
  • Zhiming Cui
    The Institute of Information Processing and Application, Soochow University, Suzhou 215006, China.

Keywords

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