Embryo metabolism as a novel non-invasive preimplantation test: nutrients turn over and metabolomic analysis of human spent embryo culture media (SECM).

Journal: Human reproduction update
Published Date:

Abstract

BACKGROUND: Single embryo transfer is globally recommended during IVF treatments. Hence, there is a growing demand for better embryo selection. Additionally, to morphology and genetics, nutrient uptake/release and metabolome profiles in spent embryo culture media (SECM) are proposed as non-invasive biomarkers. Are they ready to be applied for clinical purposes?

Authors

  • AliReza Alizadeh Moghadam Masouleh
    Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
  • Poopak Eftekhari-Yazdi
    Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
  • Amin Ebrahimi Sadrabadi
    Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACER, Tehran, Iran.
  • Reza Jafarzadeh Esfehani
    Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Mashhad, Razavi Khorasan, Iran.
  • Monica Tobler
    gyn-medicum, Center for Reproductive Medicine, Göttingen, Germany.
  • Sven Schuchardt
    Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany.
  • Luca Gianaroli
    International Institute of Reproductive Medicine, IIRM, Lugano, Switzerland.
  • Andreas Schmutzler
    gyn-medicum, Center for Reproductive Medicine, Göttingen, Germany.

Keywords

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