Deep Learning to Differentiate Parkinsonian Syndromes Using Multimodal Magnetic Resonance Imaging: A Proof-of-Concept Study.

Journal: Movement disorders : official journal of the Movement Disorder Society
Published Date: Jul 24, 2025

Abstract

BACKGROUND: The differentiation between multiple system atrophy (MSA) and Parkinson's disease (PD) based on clinical diagnostic criteria can be challenging, especially at an early stage. Leveraging deep learning methods and magnetic resonance imaging (MRI) data has shown great potential in aiding automatic diagnosis.

Authors

  • Giulia Maria Mattia
    ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France. Electronic address: giulia-maria.mattia@inserm.fr.
  • Lydia Chougar
    AP-HP, Hôpital de la Pitié Salpêtrière, Department of Neuroradiology, Paris 75013, France.
  • Alexandra Foubert-Samier
    Univ. de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
  • Wassilios G Meissner
    Univ. de Bordeaux, CNRS, IMN, UMR 5293, Bordeaux, France.
  • Margherita Fabbri
    Univ Toulouse, Inserm, ToNIC, Toulouse, France.
  • Anne Pavy-Le Traon
    Univ Toulouse, Inserm, ToNIC, Toulouse, France.
  • Olivier Rascol
    Univ Toulouse, Inserm, ToNIC, Toulouse, France.
  • David Grabli
    Département des maladies du Système Nerveux, Assistance Publique-Hôpitaux de Paris Pitié Salpêtrière, Paris, France.
  • Bertrand Degos
    Assistance Publique Hôpitaux de Paris, Service de Neurologie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine-Saint-Denis, Sorbonne Paris Nord, NS-PARK/FCRIN Network, Bobigny, France.
  • Nadya Pyatigorskaya
    Center for NeuroImaging Research (CENIR), Paris Brain Institute-ICM, Paris, France.
  • Alice Faucher
    Assistance Publique Hôpitaux de Paris, Service de Neurologie, Hôpital Avicenne, Hôpitaux Universitaires de Paris Seine-Saint-Denis, Sorbonne Paris Nord, NS-PARK/FCRIN Network, Bobigny, France.
  • Marie Vidailhet
    Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR 7225, Pitié-Salpêtrière Hospital, Paris, France.
  • Jean-Christophe Corvol
    Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR 7225, Pitié-Salpêtrière Hospital, Paris, France.
  • Stephane Lehericy
    Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Université, Inserm 1127, CNRS UMR 7225, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Centre de NeuroImagerie de Recherche, CENIR, Paris, France.
  • Patrice Péran
    ToNIC, Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France. Electronic address: patrice.peran@inserm.fr.

Keywords

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