Mycophenolate mofetil-induced colitis versus colonic graft-versus-host disease: a comparative histologic study with artificial intelligence model development.

Journal: Histopathology
Published Date: Jul 24, 2025

Abstract

AIM: The aim of this study was to compare the histopathologic features of MMF-induced colitis and colonic GVHD and develop a digital tool using deep learning convolutional neural networks (CNNs) to semi-automate the quantification of eosinophils.

Authors

  • Rofyda Elhalaby
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Priyadharshini Sivasubramaniam
    Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Benjamin J Van Treeck
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Lindsey Smith
    Rutgers Neurosurgery Health Outcomes, Policy, and Economics (H.O.P.E.) Center, New Brunswick, New Jersey.
  • Nadarra Stokes
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Won-Tak Choi
    Department of Pathology, University of California at San Francisco, San Francisco, California, USA.
  • Huaibin Mabel Ko
    Department of Pathology and Cell Biology, Columbia University, New York, New York, USA.
  • Roger K Moreira
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Christopher P Hartley
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
  • Catherine E Hagen
    Department of Pathology and Laboratory Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals