Malignancy classification of thyroid incidentalomas using 18F-fluorodeoxy-d-glucose PET/computed tomography-derived radiomics.

Journal: Nuclear medicine communications
Published Date: Jul 24, 2025

Abstract

BACKGROUND: Thyroid incidentalomas (TIs) are incidental thyroid lesions detected on fluorodeoxy-d-glucose (18F-FDG) PET/computed tomography (PET/CT) scans. This study aims to investigate the role of noninvasive PET/CT-derived radiomic features in characterizing 18F-FDG PET/CT TIs and distinguishing benign from malignant thyroid lesions in oncological patients.

Authors

  • Melda Yeghaian
    Department of Machine Learning and Neural Computing, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen 6525 GD, The Netherlands.
  • Marceline W Piek
    Departments of Surgery, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Annemarieke Bartels-Rutten
    Department of Radiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
  • Mohamed A Abdelatty
    Department of Radiology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Marina Herrero-Huertas
    Radiology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Wouter V Vogel
    Departments of Nuclear Medicine.
  • Jan Paul de Boer
    Departments of Medical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Koen J Hartemink
    Departments of Surgery, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
  • Zuhir Bodalal
    Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Regina G H Beets-Tan
    Department of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Stefano Trebeschi
    Department of Radiology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Iris M C van der Ploeg
    Departments of Surgery, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.

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