Dynamic Early Survival Prediction Model for Hepatocellular Carcinoma Patients Treated With Atezolizumab and Bevacizumab: A Longitudinal Deep Learning Analysis.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology
Published Date: Jul 23, 2025

Abstract

BACKGROUND: Atezolizumab combined with bevacizumab has become the standard first-line systemic therapy for unresectable hepatocellular carcinoma (uHCC). Although this regimen offers statistically significant and clinically meaningful benefits, accurately predicting overall survival (OS) remains a challenge. This study aims to identify potential biomarkers to improve early OS prediction in patients with uHCC treated with atezolizumab and bevacizumab.

Authors

  • Weiming Li
    Shanghai Nuanhe Brain Technology Co., Ltd, Shanghai, China.
  • Xiaoqian Xu
    National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Hao Wang
    Department of Cardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China.
  • Shun Li
    National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Lichen Shi
    School of Mechanical and Electrical Engineering, Xi'an University of Architecture and Technology, Xi'an 710055, China.
  • Cheng Huang
    James H. Clark Center, Stanford University, Stanford, California, USA.
  • Hong You
    Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Capital Medical University, Beijing, China.
  • Jidong Jia
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Youwen He
    Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA.
  • Yuanyuan Kong
    Clinical Epidemiology and Evidence-Based Medical Center, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

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