CT-based intratumoral and peritumoral radiomics to predict the treatment response to hepatic arterial infusion chemotherapy plus lenvatinib and PD-1 in high-risk hepatocellular carcinoma cases: a multi-center study.

Journal: Hepatology international
Published Date: Jul 23, 2025

Abstract

BACKGROUND: Noninvasive and precise tools for treatment response estimation in patients with high-risk hepatocellular carcinoma (HCC) who could benefit from hepatic arterial infusion chemotherapy (HAIC) plus lenvatinib and humanized programmed death receptor-1 inhibitors (PD-1) (HAIC-LEN-PD1) are lacking. This study aimed to evaluate the predictive potential of intratumoral and peritumoral radiomics for preoperative treatment response assessment to HAIC-LEN-PD1 in high-risk HCC cases.

Authors

  • Zihao Liu
  • Xinge Li
    Department of Oncology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250000, Shandong, China.
  • Yong Huang
    State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection of Ministry Education, Guangxi Normal University, Guilin 541004, China.
  • Xu Chang
    Brewing and Bioenergy Business Unit, Angel Yeast Co., Ltd, Yichang, 443003 China.
  • Hong Zhang
    Department of Anesthesiology and Operation, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
  • Xiaodong Wu
    Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, 52242, USA.
  • Yanzhao Diao
    School of Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Jinan University, Guangzhou, 518037, China.
  • Fengling He
    Department of Radiology, Caoxian County Hospital, Heze, 274499, Shandong, China.
  • Junyong Sun
    Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
  • Baomin Feng
    Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
  • Hexin Liang
    Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. lhx982707299@163.com.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals