Biological tumor volume predicts survival in recurrent High-Grade glioma: A multiparametric [F]FET PET/MRI study.

Journal: European journal of nuclear medicine and molecular imaging
Published Date: Jul 24, 2025

Abstract

BACKGROUND AND PURPOSE: Single-session, multiparametric [¹⁸F]FET PET/MRI is used to detect tumor recurrence in high-grade glioma, but its prognostic value for overall survival remains uncertain. This study evaluated whether biological tumor volume, tumor-to-background ratio (TBRmax), cerebral blood volume (rCBVmax), and choline/NAA ratio (Cho/NAA) could predict survival in recurrent high-grade glioma.

Authors

  • Dylan Henssen
    Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Michael Rullmann
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Anne I J Arens
    Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Andreas Schildan
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Stephan Striepe
    Department of Radiation Oncology, University Hospital Leipzig, Leipzig, Germany.
  • Matti Schürer
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Cordula Scherlach
    Institute for Neuroradiology, University Hospital Leipzig, Leipzig, Germany.
  • Katja Jähne
    Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.
  • Ruth Stassart
    Institute of Neuropathology, University of Leipzig, Leipzig, Germany.
  • Osama Sabri
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.
  • Clemens Seidel
    Department of Radiation Oncology, University Hospital Leipzig, Leipzig, Germany.
  • Swen Hesse
    Department of Nuclear Medicine, University Hospital Leipzig, Leipzig, Germany.

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