Multi-omic profiling reveals age-specific blood biomarkers and aging-driven B Cell remodeling in osteoarthritis.

Journal: International journal of surgery (London, England)
Published Date: Jul 23, 2025

Abstract

BACKGROUND: Osteoarthritis (OA) pathogenesis involves age-related immune dysregulation, yet non-invasive diagnostic tools and mechanistic insights remain limited.

Authors

  • Bizhi Tu
    Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, Anhui, China.
  • Run Fang
    School of Electronic and Electrical Engineering, Wuhan Textile University, Wuhan, 430200, China. rfang@wtu.edu.cn.
  • Peizhi Lu
    Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, Anhui, China.
  • Mingxiang Liu
    Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, Anhui, China.
  • Shuo Yang
    Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.
  • Dingtao Hu
    Clinical Cancer Institute, Center for Translational Medicine, Naval Medical University, 800 Xiangyin Road, Shanghai, China.
  • Renzhi Ruan
    Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, Anhui, China.
  • Rende Ning
    Department of Orthopedics, The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei), 390 Huaihe Road, Hefei, Anhui, China.

Keywords

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