Bioimpedance a Diagnostic Tool for Tobacco Induced Oral Lesions: a Mixed Model cross-sectional study
Journal:
arXiv
Published Date:
Aug 21, 2024
Abstract
Introduction: Electrical impedance spectroscopy (EIS) has recently developed
as a novel diagnostic device for screening and evaluating cervical dysplasia,
prostate cancer, breast cancer and basal cell carcinoma. The current study
aimed to validate and evaluate bioimpedance as a diagnostic tool for
tobacco-induced oral lesions. Methodology: The study comprised 50 OSCC and OPMD
tissue specimens for in-vitro study and 320 subjects for in vivo study.
Bioimpedance device prepared and calibrated. EIS measurements were done for the
habit and control groups and were compared. Results: The impedance value in the
control group was significantly higher compared to the OPMD and OSCC groups.
Diagnosis based on BIS measurements has a sensitivity of 95.9% and a
specificity of 86.7%. Conclusion: Bioimpedance device can help in
decision-making for differentiating OPMD and OSCC cases and their management,
especially in primary healthcare settings.
Keywords: Impedance, Cancer, Diagnosis, Device, Community
