Association of initial core volume on non-contrast CT using a deep learning algorithm with clinical outcomes in acute ischemic stroke: a potential tool for selection and prognosis?

Journal: Journal of neurointerventional surgery
Published Date: Jul 24, 2025

Abstract

BACKGROUND: In an extended time window, contrast-based neuroimaging is valuable for treatment selection or prognosis in patients with stroke undergoing reperfusion treatment. However, its immediate availability remains limited, especially in resource-constrained regions. We sought to evaluate the association of initial core volume (ICV) measured on non-contrast computed tomography (NCCT) by a deep learning-based algorithm with outcomes in patients undergoing reperfusion treatment.

Authors

  • Alan Flores
    Stroke Unit. Neurology Department, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
  • Xavier Ustrell
    Stroke Unit. Neurology Department, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
  • Laia Seró
    Stroke Unit. Neurology Department, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
  • Antoni Suarez
    Stroke Unit. Neurology Department, Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain.
  • Ylenia Avivar
    Institut d'Investigacio Sanitaria Pere Virgili, Tarragona, Spain.
  • Leonardo Cruz-Criollo
    Neurology Department, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
  • Milagros Galecio-Castillo
    Neurology Department, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
  • Jorge Cespedes
    Comprehensive Epilepsy Center, Yale University, New Haven, Connecticut, USA.
  • Judith Cendrero
    Methinks Software SL, Barcelona, Spain.
  • Victor Salvia
    Methinks Software SL, Barcelona, Spain.
  • Álvaro Garcia-Tornel
    Vall d'Hebron Research Institute, Passeig de la Vall d'Hebron, Barcelona, Spain (G.C., M. Ribo, M.O.-G., M.M., Á.G.-T., M. Requena, J.P., J.J., D.R.-L., N.R.-V., F.R., B.T., C.A.M., M. Rubiera).
  • Marta Olivé Gadea
    Stroke Unit, Department of Neurology, Hospital Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Spain.
  • Pere Canals
    Stroke Unit, Neurology, Vall d'Hebron University Hospital, Barcelona, Spain pere.canals@vhir.org.
  • Santiago Ortega-Gutierrez
    Neurology Department, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA santy-ortega@uiowa.edu.
  • Marc Ribo
    Stroke Unit, Neurology Department, Hospital Vall d'Hebron, Departament de Medicina, Universitat Autònoma de Barcelona (M.O.-G., M.R.).

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