Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: Cancers show heterogeneity at various levels, from genome to radiologic imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the most common group of brain tumors in children.

Authors

  • Anahita Fathi Kazerooni
    Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Adam Kraya
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Komal S Rathi
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Meen Chul Kim
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Varun Kesherwani
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Ryan Corbett
    Center for Cancer and Immunology Research (R.C.), Children's National Hospital, Washington, District of Columbia.
  • Arastoo Vossough
    Division of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Nastaran Khalili
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Deep Gandhi
    From the Center for Data Driven Discovery in Biomedicine (A.V., N.K., A.M.F., D.G., K.V., D.H., S.B., H.A., P.B.S., A.R., A.N., A.F.K.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
  • Neda Khalili
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Ariana M Familiar
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Run Jin
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Xiaoyan Huang
    Department of Cardiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310015, P.R. China.
  • Yuankun Zhu
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
  • Alex Sickler
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Matthew R Lueder
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Saksham Phul
    Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
  • Phillip B Storm
    Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jeffrey B Ware
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jessica B Foster
    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Sabine Mueller
    From the Artificial Intelligence in Medicine (AIM) Program, Mass General Brigham, Harvard Medical School, Boston, Mass (A.B., Z.Y., Y.Z., A.Z., H.H., R.C., H.J.W.L.A., B.H.K.); Department of Radiation Oncology (A.B., Z.Y., M.C.T., Y.Z., A.Z., H.H., R.C., K.X.L., D.A.H.K., H.J.W.L.A., B.H.K.) and Department of Radiology (H.J.W.L.A.), Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, 75 Francis St, Boston, MA 02115; Department of Radiology, Boston Children's Hospital, Harvard Medical School, Boston, Mass (S.P.P., S.V., T.Y.P.); Department of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health, Boston, Mass (P.J.C.); Center for Data-Driven Discovery in Biomedicine (D3b) (A.N., A.C.R.) and Department of Neurosurgery (A.C.R.), Children's Hospital of Philadelphia, Philadelphia, Pa; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa (A.N.); Departments of Neurology, Pediatrics, and Neurologic Surgery, University of California, San Francisco, San Francisco, Calif (S.M.); and Department of Radiology and Nuclear Medicine, CARIM & GROW, Maastricht University, Maastricht, the Netherlands (H.J.W.L.A.).
  • Jo Lynne Rokita
    Center for Cancer and Immunology Research (R.C.), Children's National Hospital, Washington, District of Columbia.
  • Michael J Fisher
    Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Adam C Resnick
    Center for Data-Driven Discovery in Biomedicine (D3b), The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
  • Ali Nabavizadeh
    Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Keywords

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