Comprehensive Insights into APOBEC Mutations in Thyroid Cancer: Prognostic and Therapeutic Discoveries.

Journal: Biological procedures online
Published Date:

Abstract

BACKGROUND: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family plays a vital mutagenic role in diverse human malignancies. Nevertheless, the biological characteristics of APOBEC family members and their clinical significance in cancer have not been comprehensively explored. Our primary objective was to characterize the distribution and clinical relevance of APOBEC family members and their mutations across multiple cancer types, with a particular focus on thyroid carcinoma (THCA).

Authors

  • Wei Luo
    Centre for Pattern Recognition and Data Analytics, School of Information Technology, Deakin University, Geelong, Victoria, Australia.
  • Feng Liu
    Department of Vascular and Endovascular Surgery, The First Medical Center of Chinese PLA General Hospital, 100853 Beijing, China.
  • Mengyu Li
    Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
  • Jialong Yu
    Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Henan,  China.
  • Ziyun Liu
    Pancreas Center, National Clinical Research Center for Cancer, State Key Laboratory of Drug ability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Tianjin, PR China.
  • Xuan Cheng
  • Yue Huang
    Xiamen University, Xiamen, Fujian 361005, China.
  • Yu Liu
    Research Center of Information Technology, Beijing Academy of Agriculture and Forestry Science, Beijing, China.
  • Mei Tao
    Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, No. 1, Huanhu West Road, Tianjin, 300060, China.
  • Yuqi Wang
    Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, P.R. China.
  • Yiping Zou
    Pancreas Center, National Clinical Research Center for Cancer, State Key Laboratory of Drug ability Evaluation and Systematic Translational Medicine, Tianjin Key Laboratory of Digestive Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin's Clinical Research Center for Cancer, Tianjin, PR China.
  • Xiaobin Shang
    Department of Minimally Invasive Esophageal Surgery, Tianjin Medical University Cancer Hospital and Institute, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China.
  • Chao Yang
    Translational Institute for Cancer Pain, Chongming Hospital Affiliated to Shanghai University of Health & Medicine Sciences (Xinhua Hospital Chongming Branch), Shanghai 202155, P. R. China.
  • Xianhui Ruan
    Department of Thyroid and Neck Tumor, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Yanchao Qin
    Department of Head and Neck Surgery, Shanxi Hospital Affiliated to Cancer Hospital, Cancer Hospital, Shanxi Provincial Cancer Hospital, Chinese Academy of Medical Sciences, Shanxi Medical University, Taiyuan, 031000, China. qinyanchao@sxmu.edu.cn.
  • Xiangqian Zheng
    Department of Ultrasonography, Integrated Traditional Chinese and Western Medicine Hospital, Jilin, China.

Keywords

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