A comprehensive analysis through Mendelian randomization of immunological markers and sphingolipid metabolism.

Journal: Discover oncology
Published Date: Jul 28, 2025

Abstract

BACKGROUND: Lung cancer pathogenesis involves complex interactions between immune system components and metabolic pathways. However, the causal relationships between these factors remain unclear. This study aimed to employ Mendelian randomization (MR) analysis to establish causal links between immunological markers, metabolic factors, and lung cancer development, while integrating multi-omics data for comprehensive molecular characterization.

Authors

  • Dunpeng Yang
    Department of Thoracic Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
  • Wentian Zhang
    Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Qibin Wang
    Department of Thoracic Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. wangqb0504@163.com.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals