Advances in non-invasive diagnostic tools for endometriosis: A narrative review of the past ten years.
Journal:
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Published Date:
Jul 29, 2025
Abstract
Endometriosis is a chronic condition defined by endometrium-like tissue outside the uterus, with symptoms including pain, infertility, and fatigue. Despite the high prevalence of disease, diagnosis is frequently delayed, in part due to reliance on invasive procedures such as laparoscopy. Over the past decade, scientific research and international collaborations have focused on the development of non-invasive diagnostic tools to allow earlier detection and reduce the burden of surgical diagnosis. This narrative review summarizes key developments in non-invasive tools over the past decade. These advances include those in the biomarker space, imaging techniques and protocols, and artificial intelligence applications. While no single test has yet replaced laparoscopy, significant strides have been made toward safer, earlier diagnosis. Continued interdisciplinary collaboration, standardization of imaging and research protocols, and large-scale validation studies are essential for translating these findings into clinical practice.
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