Glo-In-One-v2: holistic identification of glomerular cells, tissues, and lesions in human and mouse histopathology.

Journal: Journal of medical imaging (Bellingham, Wash.)
Published Date: Jul 28, 2025

Abstract

PURPOSE: Segmenting intraglomerular tissue and glomerular lesions traditionally depends on detailed morphological evaluations by expert nephropathologists, a labor-intensive process susceptible to interobserver variability. Our group previously developed the Glo-In-One toolkit for integrated glomerulus detection and segmentation. We leverage the Glo-In-One toolkit to version 2 (Glo-In-One-v2), which adds fine-grained segmentation capabilities. We curated 14 distinct labels spanning tissue regions, cells, and lesions across 23,529 annotated glomeruli from human and mouse histopathology data. To our knowledge, this dataset is among the largest of its kind to date.

Authors

  • Lining Yu
    Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States.
  • Mengmeng Yin
    National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China.
  • Ruining Deng
    Vanderbilt University, Nashville TN 37215, USA.
  • Quan Liu
    Vanderbilt University, Nashville, TN 37212, USA.
  • Tianyuan Yao
  • Can Cui
    Vanderbilt University, Nashville TN 37215, USA.
  • Junlin Guo
    Vanderbilt University, Department of Computer Science, Nashville, Tennessee, United States.
  • Yu Wang
    Clinical and Technical Support, Philips Healthcare, Shanghai, China.
  • Yaohong Wang
    Vanderbilt University Medical Center, Nashville TN 37232, USA.
  • Shilin Zhao
    Departments of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
  • Haichun Yang
    Vanderbilt University Medical Center, Nashville TN 37232, USA.
  • Yuankai Huo
    Vanderbilt University, Nashville, TN 37212, USA.

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