Gut microbiome in gastrointestinal neoplasms: from mechanisms to precision therapeutic strategies.

Journal: Gut pathogens
Published Date: Jul 30, 2025

Abstract

BACKGROUND: The incidence of Gastrointestinal Neoplasms (GI neoplasms) continues to increase globally. Colorectal cancer (CRC), in particular, has emerged as the second leading cause of cancer-related mortality worldwide. Now, Specific pathogenic bacteria, such as Fusobacterium nucleatum (F. nucleatum) and Helicobacter pylori (H. pylori), critically promote tumorigenesis through multiple mechanisms, including the induction of genotoxic damage, host metabolic reprogramming, and remodeling of the tumor immune microenvironment. Notably, a dysbiotic Gut Microbiome (GM) state significantly compromises patient response rates to cancer therapeutics. This review aims to systematically analyze the core molecular mechanism of GM affecting tumor development and explore the precise intervention strategies guided by clinical translation.

Authors

  • Jiaqian Song
    Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, China.
  • Wei Zhang
    The First Affiliated Hospital of Nanchang University, Nanchang, China.
  • Deqiang Wang
    School of Rehabilitation Medicine of Binzhou Medical University, Yantai, China.

Keywords

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