Connectivity-based analysis of stimulation effects of globus pallidus interna deep brain stimulation in Parkinson's disease: A focus on freezing of gait.

Journal: Journal of movement disorders
Published Date: Jul 30, 2025

Abstract

OBJECTIVE: Freezing of gait (FOG) significantly affects the quality of life and increases the risk of falls in patients with Parkinson's disease (PD). Although deep brain stimulation (DBS) of the globus pallidus interna (GPi) is effective in managing motor complications, its efficacy in treating FOG remains inconsistent. This study aimed to determine whether preoperative structural brain connectivity can predict both the presence of FOG and its postoperative improvement following GPi DBS.

Authors

  • Sungyang Jo
    From the Departments of Neurology (K.W.P., E.-J.L., S.J., M.J., J.Y.D., D.-W.K., S.J.C.) and Convergence Medicine (J.S.L., J.J., J.-G.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Electronics and Telecommunications Research Institute (J.S.L.), Gwangju; Promedius Inc (J.J.), Seoul; and Department of Neurology (N.C.), Heavenly Hospital, Goyang, Korea.
  • Moongwan Choi
    Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Jihyun Lee
    SCH Media Labs, Soonchunhyang University, Asan, Chungnam, South Korea.
  • Sangjin Lee
    Department of Cardiovascular Surgery, Spectrum Health Grand Rapids, Grand Rapids, MI, USA.
  • Hwon Heo
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Chong Hyun Suh
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Woo Hyun Shim
    Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Junhyung Kim
    Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.
  • Sang Ryong Jeon
    Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
  • Hyunna Lee
    Department of Radiology, Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
  • Sun Ju Chung
    From the Departments of Neurology (K.W.P., E.-J.L., S.J., M.J., J.Y.D., D.-W.K., S.J.C.) and Convergence Medicine (J.S.L., J.J., J.-G.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; Electronics and Telecommunications Research Institute (J.S.L.), Gwangju; Promedius Inc (J.J.), Seoul; and Department of Neurology (N.C.), Heavenly Hospital, Goyang, Korea. sjchung@amc.seoul.kr.

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