Exosomal Liquid Biopsy for the Early Detection of Gastric Cancer: The DESTINEX Multicenter Study.

Journal: JAMA surgery
Published Date: Jul 30, 2025

Abstract

IMPORTANCE: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide, primarily attributed to delayed detection. The invasive and cost-prohibitive nature of endoscopy for GC screening highlights the urgent need for noninvasive biomarkers.

Authors

  • Silei Sui
    Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, California.
  • Caiming Xu
    Beckman Research Institute of City of Hope, Monrovia, CA, United States.
  • Mitsuro Kanda
    Department of Surgery (Gastrointestinal Surgery), Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.
  • Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Japan.
  • Joon Oh Park
    Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Hoon Hur
    Department of Surgery, Ajou University School of Medicine, Suwon, South Korea.
  • Song Cheol Kim
    Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
  • Akinobu Taketomi
    Department of Gastroenterological Surgery I Graduate School of Medicine Hokkaido University Sapporo Japan.
  • Yasuhiro Kodera
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Xiangdong Cheng
    Department of Gastric Surgery.
  • Man Li
    Department of Psychogeriatrics, Kangci Hospital of Jiaxing, Tongxiang, Zhejiang, China.
  • Ajay Goel
    Department of Molecular Diagnostics and Experimental Therapeutics, Beckman Research Institute of City of Hope, Biomedical Research Center, Monrovia, California.

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