Comprehensive analysis of cholesterol metabolism-related genes in prostate cancer: integrated analysis of single-cell and bulk RNA sequencing.

Journal: Discover oncology
Published Date: Jul 30, 2025

Abstract

BACKGROUND: Cholesterol metabolism plays a significant role in cancer progression, including prostate adenocarcinoma (PRAD), making it a promising target for therapeutic intervention. This study aimed to construct and validate a cholesterol metabolism gene (CMG)-related prognostic signature to predict prognosis in PRAD patients, while exploring its biological, clinical, and therapeutic implications.

Authors

  • Zixiong Jiang
    International Medical College, Chongqing Medical University, Chongqing, China.
  • Yu Luo
    Department of Radiology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China.
  • Liangdong Song
    Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Jindong Zhang
    Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
  • Chengcheng Wei
    Department of Urology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Shuai Su
    Department of Urology, Urologic Surgery Center, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China. sushuai930809@163.com.
  • Delin Wang
    Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China. Electronic address: dlwangws@sina.com.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals