Electroencephalogram Features Distinguish Cases of Cerebral Malaria Among Malawian Children With Fever and Coma.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Published Date:

Abstract

BACKGROUND: In febrile comatose patients living in malaria-endemic areas, overlapping symptoms and limited laboratory capacity make it difficult to distinguish parasitic, bacterial, and viral central nervous system infections. We evaluated electroencephalography (EEG) as a biomarker to differentiate the microbiologic etiology of pediatric febrile coma at a major referral center in Malawi.

Authors

  • Alexander Andrews
    Division of Neurology, The George Washington University/Children's National Hospital, Washington D.C., USA.
  • Dana B Harrar
    Division of Neurology, The George Washington University/Children's National Hospital, Washington D.C., USA.
  • Tesfaye Zelleke
    Division of Neurology, The George Washington University/Children's National Hospital, Washington D.C., USA.
  • Jiahui Zhang
    Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
  • Bo Zhang
    Department of Clinical Pharmacology, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, PR China.
  • John Barber
    Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington D.C., USA.
  • Rohini Dasan
    The George Washington University, School of Medicine and Health Sciences, Washington D.C., USA.
  • Nathaniel Amoah
    The George Washington University, School of Medicine and Health Sciences, Washington D.C., USA.
  • Olivia Findorff
    University of Virginia, Charlottesville, Virginia, USA.
  • Sean Krieger
    College of Osteophatic Medicine, Michigan State University, East Lansing, Michigan, USA.
  • Emmalee Barrett
    The George Washington University, School of Medicine and Health Sciences, Washington D.C., USA.
  • Nicole O'Brien
    Blantyre Malaria Project, Kamuzu University of Health Sciences/University of Malawi College of Medicine, Blantyre, Malawi.
  • Charlotte E Fuller
    Blantyre Malaria Project, Kamuzu University of Health Sciences/University of Malawi College of Medicine, Blantyre, Malawi.
  • Christopher A Moxon
    Blantyre Malaria Project, Kamuzu University of Health Sciences/University of Malawi College of Medicine, Blantyre, Malawi.
  • Terrie E Taylor
    College of Osteophatic Medicine, Michigan State University, East Lansing, Michigan, USA.
  • Michael J Griffiths
    Centre for Child and Adolescent Health Research, Western Sydney (Baludarri) Precinct, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
  • Stephen T J Ray
    Blantyre Malaria Project, Kamuzu University of Health Sciences/University of Malawi College of Medicine, Blantyre, Malawi.
  • Douglas G Postels
    Division of Neurology, The George Washington University/Children's National Hospital, Washington D.C., USA.

Keywords

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