Multi-omics identification of circulating protein biomarkers for intervertebral disc degeneration using Mendelian randomization and scRNA-seq.

Journal: Clinical rheumatology
Published Date: Jul 31, 2025

Abstract

BACKGROUND: Intervertebral disc degeneration (IVDD) is a primary cause of chronic low back pain, significantly impacting quality of life and healthcare systems globally. Despite its prevalence, the molecular mechanisms underlying IVDD remain unclear, and effective biomarkers are lacking. This study aims to identify circulating protein biomarkers causally linked to IVDD and explore their potential as biomarkers.

Authors

  • Fan Bai
    School of Information Engineering, Chang'an University, Xi'an 710010, China.
  • Lingting Wang
    Spinal Surgery Division, Yijishan Hospital, Wannan Medical College, 2 Zheshan West Road, Jinghu District, Wuhu, 241000, Anhui, China.
  • He Liu
    Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
  • Yufei He
    Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Engineering Medicine, School of Biological Science and Medical Engineering, Beihang University, No.37 Xueyuan Road, Haidian District, Beijing, 100083, People's Republic of China.
  • Hong Wang
    Department of Cardiology, Liuzhou Workers' Hospital, The Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China.

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