Artificial Intelligence and the Evolving Landscape of Immunopeptidomics.

Journal: Proteomics. Clinical applications
Published Date: Jul 31, 2025

Abstract

BACKGROUND: Immunopeptidomics is the large-scale study of peptides presented by major histocompatibility complex (MHC) molecules and plays a central role in neoantigen discovery and cancer immunotherapy. However, the complexity of mass spectrometry data, the diversity of peptide sources, and variability in immune responses present major challenges in this field.

Authors

  • Thanh Hoa Vo
    Department of Science, School of Science and Computing, South East Technological University, Waterford X91 K0EK, Ireland.
  • Edel McNeela
    Department of Science, Pharmaceutical and Molecular Biotechnology Research Center (PMBRC), South East Technological University, Waterford, Ireland.
  • Orla O'Donovan
    Department of Science, Pharmaceutical and Molecular Biotechnology Research Center (PMBRC), South East Technological University, Waterford, Ireland.
  • Sweta Rani
    Department of Science, Pharmaceutical and Molecular Biotechnology Research Center (PMBRC), South East Technological University, Waterford, Ireland.
  • Jai Prakash Mehta
    Department of Applied Science, South East Technological University, Carlow, Ireland.

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