A Radiogenomic Deep Ensemble Learning Model for Identifying Radionecrosis Following Brain Metastases (BM) Stereotactic Radiosurgery in Patients With Non-small Cell Lung Cancer BM.

Journal: Advances in radiation oncology
Published Date: Jul 2, 2025

Abstract

PURPOSE: Stereotactic radiosurgery (SRS) is widely used for brain metastases (BM), but the risk of radionecrosis poses a challenge in post-SRS management. Given the lack of noninvasive imaging methods for distinguishing radionecrosis from recurrence, we aimed to design a deep ensemble learning model that integrates patient clinical features and genomic profiles to identify radionecrosis in patients with BM with post-SRS radiographic progression.

Authors

  • Jingtong Zhao
    Duke University Medical Center, Durham, North Carolina.
  • Eugene Vaios
    Duke University Medical Center, Durham, North Carolina.
  • Evan Calabrese
    Department of Radiology and Biomedical Imaging, University of California At San Francisco, 350 Parnassus Ave, Suite 307H, San Francisco, CA, 94143-0628, USA. evan.calabrese@ucsf.edu.
  • Zhenyu Yang
    College of Electronic Engineering (College of Artificial Intelligence), South China Agricultural University, Guangzhou, China.
  • Scott Robertson
    Pathology and Laboratory Medicine Institute (PLMI), Cleveland Clinic, Cleveland, OH, United States; PLMI's Center for Artificial Intelligence & Data Science, Cleveland Clinic, Cleveland, OH, United States.
  • John Ginn
    Department of Radiation Oncology, Duke Cancer Center, Duke University, Durham, North Carolina, USA.
  • Ke Lu
    University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China. Electronic address: luk@ucas.ac.cn.
  • Fang-Fang Yin
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States.
  • Zachary Reitman
    Deparment of Radiation Oncology, Duke University, Durham, North Carolina.
  • John Kirkpatrick
    Duke University Medical Center, Durham, North Carolina.
  • Scott Floyd
    Duke University Medical Center, Durham, North Carolina.
  • Peter Fecci
    Duke University Medical Center, Durham, North Carolina.
  • Chunhao Wang
    Department of Radiation Oncology, Duke University Medical Center, Durham, NC, United States.

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