Machine learning-based radiomics models for the prediction of metachronous liver metastases in patients with colorectal cancer: A multimodal study.

Journal: Oncology letters
Published Date: Jun 11, 2025

Abstract

The aim of the present study was to investigate whether a multimodal radiomics model powered by machine learning could accurately predict the occurrence of metachronous liver metastasis (MLM) in patients with colorectal cancer (CRC). A total of 157 patients diagnosed with CRC between 2010 and 2020 were retrospectively included in the present study; of these patients, 67 patients developed liver metastases within 2 years of treatment, while the remaining patients (n=90) did not. Radiomics features were extracted from annotated MR images of the tumor and portal venous phase CT images of the liver in each patient. Subsequently, machine learning-based radiomics models were developed and integrated with the clinical features for MLM prediction, employing Least Absolute Shrinkage and Selection Operator and Random Forest algorithms. The performance of the models were evaluated using the receiver operating characteristic curve analysis, while the clinical utility was measured using the decision curve analysis. A total of 922 and 1,082 radiomics features were extracted from the MR and CT images of each patient, respectively, which quantified the intensity, shape, orientation and texture of the tumor and liver. The mean area under the curve (AUC) values for the prediction of MLM were 0.80, 0.68 and 0.82 for the CT, MRI and merged models, respectively. For the clinical and clinical-merged models, the AUC values were 0.62 and 0.75, respectively. There was no significant difference between the CT model and the merged model (P>0.05). In conclusion, the preliminary results of the present study demonstrated the utility of machine learning-based radiomics models in the prediction of MLM in patients with CRC. However, further research is warranted to explore the potential of multimodal fusion models, due to the minimal improvement observed in diagnostic performance.

Authors

  • Jian-Ping Wang
    Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangzhou, Guangdong, P. R. China.
  • Ze-Ning Zhang
    Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.
  • Ding-Bo Shu
    Department of Radiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China.
  • Ya-Nan Huang
    Department of Radiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China.
  • Wei Tang
    Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
  • Hong-Bo Zhao
    Department of Radiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China.
  • Zhen-Hua Zhao
    Department of Radiology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China.
  • Ji-Hong Sun
    Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, P.R. China.

Keywords

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