Identification of m5C-related genes and subclusters in recurrent pregnancy loss.

Journal: Journal of assisted reproduction and genetics
Published Date: Aug 2, 2025

Abstract

PURPOSE: Recurrent pregnancy loss (RPL), which occurs in 1-5% of couples and nearly half of the cases remain unexplained, is a complex condition influenced by multiple factors. Previous investigations have demonstrated the role of m5C-related genes (MRGs) in cancer prognosis and the significance of epigenetic modifications during pregnancy. However, the connection between MRGs and the pathogenesis of RPL remains elusive. This study endeavors to elucidate this relationship through bioinformatics approaches.

Authors

  • Huanmin Luo
    Department of Obstetrics and Gynecology, Perinatal Medical Center, The Fifth Affiliated Hospital of Sun Yat-sen University, 52 Meihua East Road, Xiangzhou District, Zhuhai, Guangdong, 519000, China.
  • Shuqing Li
    College of Information Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China.
  • Yuming Cao
    Department of Obstetrics and Gynecology, Perinatal Medical Center, The Fifth Affiliated Hospital of Sun Yat-sen University, 52 Meihua East Road, Xiangzhou District, Zhuhai, Guangdong, 519000, China.
  • Jinfeng Xu
    Department of Ultrasound, The Second Clinical Medical Collegeļ¼ŒJinan University, Guangdong, China.
  • Li Wang
    College of Marine Electrical Engineering, Dalian Maritime University, Dalian, China.

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