Plant-Derived Bioactive Peptides: Extraction, Isolation, Purification, Pharmacological Activities, Structure-Activity Relationship, and Applications.

Journal: Journal of agricultural and food chemistry
Published Date:

Abstract

Plant-derived bioactive peptides (PDBPs) have become a key research focus owing to their multiple targets and high safety. However, current challenges in this field primarily include the low efficiency of traditional extraction techniques, the complex structure-activity relationships of PDBPs, the scalability of novel technologies, inadequate understanding of multisystem synergistic effects, and the scarcity of human clinical trials. To address these gaps, future research should integrate artificial intelligence to establish an integrated technological system spanning computer-aided design, targeted preparation, and activity verification, while prioritizing efforts to elucidate the mechanisms of multisystem synergism, develop environmentally friendly extraction processes and targeted delivery systems, and facilitate the translation of PDBPs from basic research to functional products. This review integrates food science, biotechnology, and pharmacology to analyze PDBPs structures, techniques, and cross-system actions, providing a theoretical and technological roadmap for applications in foods, pharmaceuticals, and cosmetics.

Authors

  • Yanli Chen
    Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
  • Jiteng Sun
    College of Pharmaceutical, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
  • Haixia Chen
    Department of Oncology Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
  • Yue Yang
    Department of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China.
  • JiaYu Zhang
    The Department of Radiology, Jiangmen Central Hospital/Affiliated Jiangmen Hospital of Sun Yat-Sen University, No. 23 Haibang Street, Jiangmen, 529000, Guangdong, China.
  • Shaoping Wang
  • Daoming Bai
    College of Pharmaceutical, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
  • Zhiqiang Sun
    Shandong Yuze Pharmaceutical Industry Technology Research, Dezhou 251200, China.
  • Jing Song
    School of Economics and Management, Tsinghua University, Beijing, China.
  • Long Dai
    School of Pharmacy, Binzhou Medical University, Yantai 264003, China.

Keywords

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