Gene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease.

Journal: Discover oncology
Published Date: Aug 4, 2025

Abstract

PURPOSE: Mucosa-associated lymphoid tissue (MALT) lymphoma in the orbital region and IgG4-related ophthalmic disease (IgG4-ROD) account for the majority of mass lesions in the orbital region. These diseases may show similar shadows on radiologic images, and many cases are difficult to differentiate clinically. Using histology, we investigated the gene expression clusters (RNA-seq) and molecular differences responsible for these two diseases.

Authors

  • Mizuki Tagami
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Keishiro Isayama
    Institute of Gene Research, Yamaguchi University Science Research Center, Yamaguchi, Japan.
  • Mizuho Nishio
    Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
  • Atsuko Yoshikawa
    Ophthalmology Department and Eye Center, Kobe Kaisei Hospital, Kobe, Hyogo, Japan.
  • Norihiko Misawa
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Atsushi Sakai
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Yusuke Haruna
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Mami Tomita
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
  • Yoichi Mizukami
    Institute of Gene Research, Yamaguchi University Science Research Center, Yamaguchi, Japan.
  • Atsushi Azumi
    Ophthalmology Department and Eye Center, Kobe Kaisei Hospital, Kobe, Hyogo, Japan.
  • Shigeru Honda
    Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.

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