Framework to Select Multi-Cancer Detection Assays in the National Cancer Institute's Vanguard Study.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Published Date: Aug 4, 2025

Abstract

BACKGROUND: The Cancer Screening Research Network (CSRN) is a new clinical trials network funded by the National Cancer Institute. The first CSRN study, the Vanguard Study, will assess the feasibility of using multi-cancer detection (MCD) tests in future randomized controlled trials.

Authors

  • Elyse LeeVan
    National Cancer Institute, Rockville, MD, United States.
  • Amanda L Skarlupka
    National Cancer Institute, United States.
  • Christos Patriotis
    National Cancer Institute, Rockville, MD, United States.
  • Wendy S Rubinstein
    National Institutes of Health, Rockville, MD, United States.
  • Paul F Pinsky
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
  • Wade Bolton
    VentureWell, United States.
  • Anthony Dickherber
    National Cancer Institute, Bethesda, MD, United States.
  • Daniel C Edelman
    National Cancer Institute, Rockville, Maryland, United States.
  • Lyndsay Harris
    National Cancer Institute, Rockville, MD, United States.
  • Hormuzd A Katki
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland.
  • Erin B Lavik
    National Cancer Institute, Bethesda, MD, United States.
  • Albine Martin
    VentureWell, United States.
  • Mary Jane C Ong
    National Cancer Institute, Rockville, MD, United States.
  • Philip C Prorok
    National Cancer Institute, Bethesda, United States.
  • David Ransohoff
    University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.
  • Sarah M Temkin
    National Institutes of Health, Bethesda, MD, United States.
  • Lori M Minasian
    Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.

Keywords

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