Integrating cell-free DNA methylation of SEPT9 and SFRP2 into a machine learning model for early diagnosis of HCC.
Journal:
Biomarkers in medicine
Published Date:
Aug 4, 2025
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC), a primary contributor to cancer-associated mortality, necessitates enhanced early detection. This study evaluated machine learning models that merge methylated SEPTIN9 (SEPT9) and secreted frizzled-related protein 2 (SFRP2) within circulating cell-free DNA (cfDNA) to detect HCC.
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