Hot Topics: Exploring Artificial Intelligence and Inflammatory Memory in the Management of Psoriatic Diseases.

Journal: The Journal of rheumatology
Published Date: Aug 5, 2025

Abstract

The "hot topics" session of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) 2024 annual meeting and trainee symposium explored the integration of artificial intelligence (AI) in managing psoriatic diseases (PsD) and the underlying mechanisms of inflammatory memory that drive recurrence in psoriasis and psoriatic arthritis. Drs. April Armstrong and Denis Poddubnyy discussed the transformative role of AI in enhancing diagnostic accuracy, assessing disease severity, and predicting treatment responses, particularly through deep learning models such as convolutional neural networks. AI systems have shown promise in providing objective, standardized assessments for psoriasis, with applications expanding across dermatology and rheumatology. Dr. Liv Eidsmo presented insights into inflammatory memory, a phenomenon sustained by both immune and nonimmune cells, including tissue-resident memory cells and epigenetically altered keratinocytes. Eidsmo emphasized the importance of understanding the cellular and molecular pathways that contribute to disease persistence. Both AI and inflammatory memory highlight key challenges and opportunities in PsD management; future research is needed to integrate technological advancements, with a deeper understanding of the biological processes affecting treatment outcomes.

Authors

  • Huidi Shucheng
    H. Shucheng, MD, PhD, MPH, Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China, and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • April W Armstrong
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Liv Eidsmo
    L. Eidsmo, MD, PhD, Department of Medicine, Karolinska Institute, Stockholm, Sweden.
  • Denis Poddubnyy
    Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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