Development and Validation of DIANA (Diabetes Novel Subgroup Assessment tool): A web-based precision medicine tool to determine type 2 diabetes endotype membership and predict individuals at risk of microvascular disease.

Journal: PLOS digital health
Published Date: Aug 5, 2025

Abstract

BACKGROUND: Previous research has identified four distinct endotypes of type 2 diabetes in Asian Indians, which include Severe Insulin Deficient Diabetes (SIDD), Combined Insulin Resistant and Deficient Diabetes (CIRDD), Insulin Resistance and Obese Diabetes (IROD), and Mild Age-related Diabetes (MARD). DIANA (Diabetes Novel Subgroup Assessment) is an online precision medicine tool that can predict endotype membership of type 2 diabetes and individual risk for retinopathy and nephropathy.

Authors

  • Viswanathan Baskar
    Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence), Chennai, Tamil Nadu, India.
  • Mani Arun Vignesh
    Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence), Chennai, Tamil Nadu, India.
  • Sumanth C Raman
    Algorithm Health, Chennai, Tamil Nadu, India.
  • Arun Jijo
    Algorithm Health, Chennai, Tamil Nadu, India.
  • Bhavadharini Balaji
    Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence), Chennai, Tamil Nadu, India.
  • Nico Steckhan
    Digital Health, Hasso Plattner Institute, University of Potsdam, 14482, Potsdam, Germany. nico.steckhan@hpi.de.
  • Lena Maria Klara Roth
    Faculty of Medicine, TU Dresden, Dresden, Germany.
  • Moneeza K Siddiqui
    Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
  • Saravanan Jebarani
    Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence), Chennai, Tamil Nadu, India.
  • Ranjit Unnikrishnan
    Madras Diabetes Research Foundation (ICMR-Collaborating Centre of Excellence), Chennai, Tamil Nadu, India.
  • Viswanathan Mohan
    Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai 600086, India.
  • Ranjit Mohan Anjana
    Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai 600086, India.

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