Best Machine Learning Model for Predicting Axial Symptoms After Unilateral Laminoplasty: Based on C2 Spinous Process Muscle Radiomics Features and Sagittal Parameters.

Journal: Global spine journal
Published Date: Aug 7, 2025

Abstract

Study DesignRetrospective study.ObjectiveTo develop a machine learning model for predicting axial symptoms (AS) after unilateral laminoplasty by integrating C2 spinous process muscle radiomics features and cervical sagittal parameters.MethodsIn this retrospective study of 96 cervical myelopathy patients (30 with AS, 66 without) who underwent unilateral laminoplasty between 2018-2022, we extracted radiomics features from preoperative MRI of C2 spinous muscles using PyRadiomics. Clinical data including C2-C7 Cobb angle, cervical sagittal vertical axis (cSVA), T1 slope (T1S) and C2 muscle fat infiltration are collected for clinical model construction. After LASSO regression feature selection, we constructed six machine learning models (SVM, KNN, Random Forest, ExtraTrees, XGBoost, and LightGBM) and evaluated their performance using ROC curves and AUC.ResultsThe AS group demonstrated significantly lower preoperative C2-C7 Cobb angles (12.80° ± 7.49° vs 18.02° ± 8.59°, = .006), higher cSVA (3.01 cm ± 0.87 vs 2.46 ± 1.19 cm, = .026), T1S (26.68° ± 5.12° vs 23.66° ± 7.58°, = .025) and higher C2 muscle fat infiltration (23.73 ± 7.78 vs 20.62 ± 6.93 = .026). Key radiomics features included local binary pattern texture features and wavelet transform characteristics. The combined model integrating radiomics and clinical parameters achieved the best performance with test AUC of 0.881, sensitivity of 0.833, and specificity of 0.786.ConclusionThe machine learning model based on C2 spinous process muscle radiomics features and clinical parameters (C2-C7 Cobb angle, cSVA, T1S and C2 muscle infiltration) effectively predicts AS occurrence after unilateral laminoplasty, providing clinicians with a valuable tool for preoperative risk assessment and personalized treatment planning.

Authors

  • Bin Zheng
    School of Electrical and Computer Engineering, University of Oklahoma, 101 David L. Boren Blvd, Norman, OK, 73019, USA.
  • Zhenqi Zhu
    Spine Surgery, Peking University People's Hospital, Beijing, China.
  • Yan Liang
    Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ, 85721, United States.
  • Haiying Liu
    School of Economics and Management, Changchun University of Technology, Changchun, 130012, China. 593736059@qq.com.

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