Prediction of Benign and Malignant Small Renal Masses Using CT-Derived Extracellular Volume Fraction: An Interpretable Machine Learning Model.

Journal: Academic radiology
Published Date: Aug 9, 2025

Abstract

RATIONALE AND OBJECTIVES: We developed a machine learning model comprising morphological characteristics, enhancement dynamics, and extracellular volume (ECV) fractions for distinguishing malignant and benign small renal masses (SRMs), supporting personalised management.

Authors

  • Yunyu Guo
    Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.); Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.).
  • Qiaofang Fang
    Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.); Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.).
  • Youling Li
    Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.); Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.).
  • Dandan Yang
    Center of Clinical Pharmacology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
  • Linkai Chen
    Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.); Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.).
  • Guanghui Bai
    Department of Radiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.); Key Laboratory of Structural Malformations in Children of Zhejiang Province, Wenzhou, Zhejiang Province, China (Y.G., Q.F., Y.L., D.Y., L.C., G.B.). Electronic address: bghu79@126.com.

Keywords

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