Comparative analysis of tumor and mesorectum radiomics in predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer.

Journal: Diagnostic and interventional radiology (Ankara, Turkey)
Published Date: Aug 12, 2025

Abstract

PURPOSE: Neoadjuvant chemoradiotherapy (CRT) is known to increase sphincter preservation rates and decrease the risk of postoperative recurrence in patients with locally advanced rectal tumors. However, the response to CRT in patients with locally advanced rectal cancer (LARC) varies significantly. The objective of this study was to compare the performance of models based on radiomics features of the tumor alone, the mesorectum alone, and a combination of both in predicting tumor response to neoadjuvant CRT in LARC.

Authors

  • Ali Cantürk
    University of Health Sciences Türkiye, Department of Radiology, İstanbul, Türkiye.
  • Raif Can Yarol
    Dokuz Eylül University Faculty of Medicine, Department of Radiology, İzmir, Türkiye.
  • Ali Samet Tasak
    Ministry of Health, Department of Radiology, Ağrı, Türkiye.
  • Hakan Gülmez
    İzmir Demokrasi University Faculty of Medicine, Department of Family Medicine, İzmir, Türkiye.
  • Kenan Kadirli
    Sultan 2. Abdülhamid Han Training and Research Hospital, Clinic of Radiology, İstanbul, Türkiye.
  • Tayfun Bişgin
    Dokuz Eylül University Faculty of Medicine, Department of General Surgery, İzmir, Türkiy.
  • Berke Manoğlu
    Dokuz Eylül University Faculty of Medicine, Department of General Surgery, İzmir, Türkiy.
  • Selman Sökmen
    Dokuz Eylül University Faculty of Medicine, Department of General Surgery, İzmir, Türkiy.
  • İlhan Öztop
    Dokuz Eylül University Faculty of Medicine, Department of Medical Oncology, İzmir, Türkiye.
  • İlknur Görken Bilkay
    Dokuz Eylül University Faculty of Medicine, Department of Medical Oncology, İzmir, Türkiye.
  • Ozgul Sagol
    Department of Pathology, Dokuz Eylul University School of Medicine, Inciralti, Izmir 35340, Turkey.
  • Sülen Sarıoğlu
    Memorial Şişli Hospital, Department of Pathology, İstanbul, Türkiye.
  • Funda Barlık
    Dokuz Eylül University Faculty of Medicine, Department of Radiology, İzmir, Türkiye.

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