Sarcopenia Assessment Using Fully Automated Deep Learning Predicts Cardiac Allograft Survival in Heart Transplant Recipients.

Journal: Circulation. Heart failure
Published Date: Aug 20, 2025

Abstract

BACKGROUND: Sarcopenia is associated with adverse outcomes in patients with end-stage heart failure. Muscle mass can be quantified via manual segmentation of computed tomography images, but this approach is time-consuming and subject to interobserver variability. We sought to determine whether fully automated assessment of radiographic sarcopenia by deep learning would predict heart transplantation outcomes.

Authors

  • Frederick M Lang
    NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, US.
  • Jianfei Liu
  • Kevin J Clerkin
    Division of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. (K.J.C., E.A.D., A.J.E., G.T.S., N.U., V.K.T.).
  • Elissa A Driggin
    Division of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. (K.J.C., E.A.D., A.J.E., G.T.S., N.U., V.K.T.).
  • Andrew J Einstein
    Division of Cardiology, Department of Medicine, Columbia University Medical Center and New York-Presbyterian Hospital, New York, New York; Department of Radiology, Columbia University Medical Center and New York-Presbyterian Hospital, New York, New York.
  • Gabriel T Sayer
    Division of Cardiology, Department of Medicine, NewYork-Presbyterian Hospital/Columbia University Irving Medical Center. (K.J.C., E.A.D., A.J.E., G.T.S., N.U., V.K.T.).
  • Koji Takeda
    Division of Cardiac, Thoracic and Vascular Surgery, Department of Surgery, NewYork-Presbyterian/Columbia University Irving Medical Center (K.T.).
  • Nir Uriel
    Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.
  • Ronald M Summers
    National Institutes of Health, Clinical Center, Radiology and Imaging Sciences, 10 Center Drive, Bethesda, MD 20892, USA.
  • Veli K Topkara
    Division of Cardiology, Department of Medicine, Columbia University Irving Medical Center, New York, NY.

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