Trans-omics analyses identify the biochemical network of LPCAT1 associated with coronary artery disease.

Journal: Biomarker research
Published Date: Aug 20, 2025

Abstract

BACKGROUND: Coronary artery disease (CAD) remains a leading cause of mortality in developed nations. While previous genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) linked to CAD, their impact on disease progression requires trans-omics validation.

Authors

  • Paul Wei-Che Hsu
    Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
  • Chi-Hsiao Yeh
    Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
  • Chi-Jen Lo
    Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
  • Tsung-Hsien Tsai
    Advanced Tech BU, Acer Inc, New Taipei City, Taiwan.
  • Yun-Hsuan Chan
    Advanced Tech BU, Acer Inc, New Taipei City, Taiwan.
  • Yi-Ju Chou
    Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
  • Ning-I Yang
    Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
  • Mei-Ling Cheng
    Metabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
  • Wayne Huey-Herng Sheu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
  • Chi-Chun Lai
    Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 333.
  • Huey-Kang Sytwu
    National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
  • Ting-Fen Tsai
    Department of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Keywords

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