Clinical risk assessment of serum creatinine abnormalities during vancomycin therapy: a retrospective study using machine learning models.

Journal: International journal of clinical pharmacy
Published Date: Aug 19, 2025

Abstract

INTRODUCTION: Vancomycin is a widely used antibiotic for the treatment of serious Gram-positive bacterial infections. However, its clinical utility is often limited by the risk of nephrotoxicity, typically reflected by abnormalities in serum creatinine levels, which may indicate the occurrence of acute kidney injury (AKI). Timely identification of patients at increased risk is essential for early intervention and improved clinical outcomes.

Authors

  • Yilei Yang
    The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
  • Haiying Yan
    Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.
  • Xiangyue Wang
    School of Pharmaceutical Sciences, Shandong University, Jinan, 250014, China.
  • Jiahui Lao
    Center for Big Data Research in Health and Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
  • Ruiqiu Zhang
    Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, China.
  • Zhaoyang Chen
    Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, Shandong250014, China.
  • Shiyu Ma
    Department of Hematology, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Yan Li
    Interdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China.
  • Xiao Li
    Department of Inner Mongolia Clinical Medicine College, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Keywords

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