Analysis of potential molecular targets and mechanisms of brominated flame retardants in causing osteoarthritis using network toxicology, machine learning, SHAP analysis, and molecular dynamics simulation.

Journal: BMC pharmacology & toxicology
Published Date: Aug 18, 2025

Abstract

BACKGROUND: The commonly used brominated flame retardant (2,2’,4,4’-Tetrabromodiphenyl Ether, BDE-47) is a persistent organic pollutant that is widely distributed in the environment and is associated with adverse health effects, including an increased risk of osteoarthritis. However, the specific molecular mechanisms by which BDE-47 contributes to the development of osteoarthritis (OA) remain largely unclear. This study aimed to investigate the potential relationship between BDE-47 exposure and osteoarthritis pathogenesis.

Authors

  • Yu Liu
    Research Center of Information Technology, Beijing Academy of Agriculture and Forestry Science, Beijing, China.
  • Guohang Shen
    Women and Children's Center of the Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Shunqing District, Nanchong City, Sichuan Province, 637000, China.
  • Zidong Xia
    Women and Children's Center of the Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Shunqing District, Nanchong City, Sichuan Province, 637000, China.
  • Ruoyan Wang
    North Sichuan Medical College, No. 234 Fu Jiang Road, Shunqing, Nanchong, Sichuan, 637000, P. R. China.
  • Yupei Dai
    Women and Children's Center of the Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Shunqing District, Nanchong City, Sichuan Province, 637000, China. 1428421664@qq.com.

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