Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition.

Journal: Journal of magnetic resonance imaging : JMRI
Published Date: Aug 20, 2025

Abstract

BACKGROUND: Ayahuasca is an Amazonian psychedelic brew that contains dimethyltryptamine (DMT) and beta carbolines. Prolonged use has shown changes in cognitive-behavioral tasks, and in humans, there is evidence of changes in cortical thickness and an increase in neuroplasticity factors that could lead to modifications in functional neural circuits.

Authors

  • Lucas Rego Ramos
    Laboratory of Neuroimaging and Psychophysiology, Instituto de Psiquiatria, Faculdade de Medicina - Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Orlando Fernandes
    Laboratory of Neuroimaging and Psychophysiology, Instituto de Psiquiatria, Faculdade de Medicina - Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
  • Tiago Arruda Sanchez
    Laboratory of Neuroimaging and Psychophysiology, Instituto de Psiquiatria, Faculdade de Medicina - Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. tiago@medicina.ufrj.br.

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