Deep Learning Model for Breast Shear Wave Elastography to Improve Breast Cancer Diagnosis (INSPiRED 006): An International, Multicenter Analysis.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Published Date:

Abstract

PURPOSE: Shear wave elastography (SWE) has been investigated as a complement to B-mode ultrasound for breast cancer diagnosis. Although multicenter trials suggest benefits for patients with Breast Imaging Reporting and Data System (BI-RADS) 4(a) breast masses, widespread adoption remains limited because of the absence of validated velocity thresholds. This study aims to develop and validate a deep learning (DL) model using SWE images (artificial intelligence [AI]-SWE) for BI-RADS 3 and 4 breast masses and compare its performance with human experts using B-mode ultrasound.

Authors

  • Lie Cai
    Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • André Pfob
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Richard G Barr
    Northeastern Ohio Medical University, Youngstown, OH.
  • Volker Duda
    Department of Gynecology and Obstetrics, University of Marburg, Marburg, Germany.
  • Zaher Alwafai
    Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany.
  • Corinne Balleyguier
    Department of Radiology, Gustave Roussy Cancer Campus, Villejuif, France; Université Paris-Saclay, Paris, France.
  • Dirk-André Clevert
    Department of Radiology, University Hospital Munich-Grosshadern, Munich, Germany.
  • Sarah Fastner
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Christina Gomez
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Manuela Goncalo
    Department of Radiology, University of Coimbra, Coimbra, Portugal.
  • Ines Gruber
    Department of Gynecology and Obstetrics, University of Tuebingen, Tuebingen, Germany.
  • Markus Hahn
    Department of Gynecology and Obstetrics, University of Tuebingen, Tuebingen, Germany.
  • Panagiotis Kapetas
    Division of Molecular and Gender Imaging, Department of Biomedical Imaging and Image-Guided Therapy.
  • Juliane Nees
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Ralf Ohlinger
    Department of Gynecology and Obstetrics, University of Greifswald, Greifswald, Germany.
  • Fabian Riedel
    Department of Gynecology and Obstetrics, Heidelberg University Hospital, Heidelberg, Germany.
  • Matthieu Rutten
    From the Diagnostic Image Analysis Group, Radboud University Medical Center, Geert Groteplein 10, Nijmegen 6500 HB, the Netherlands (K.M., E.T.S., S.S., C.M.S., B.v.G.); Department of Radiology, Bernhoven Hospital, Uden, the Netherlands (H.S.); Department of Radiology, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands (A.J.G.K., M.B.J.M.K., T.S., M.R.); Department of Radiology, Meander Medisch Centrum, Amersfoort, the Netherlands (C.M.S.); and Thirona, Nijmegen, the Netherlands (R.H.H.M.P., A.M., J.M.).
  • Anne Stieber
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Riku Togawa
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Chris Sidey-Gibbons
    MD Anderson Center for INSPiRED Cancer Care, University of Texas, Houston, TX, United States.
  • Mitsuhiro Tozaki
    Department of Radiology, Sagara Hospital, 3-31 Matsubara-cho, Kagoshima City, Kagoshima, 892-0833, Japan.
  • Sebastian Wojcinski
    Department of Gynecology and Obstetrics, Breast Cancer Center, Klinikum Bielefeld Mitte GmbH, Bielefeld, Germany.
  • Joerg Heil
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany.
  • Michael Golatta
    University Breast Unit, Department of Obstetrics and Gynecology, Heidelberg University Hospital, Im Neuenheimer Feld 440, 69120, Heidelberg, Germany. Michael.golatta@med.uni-heidelberg.de.

Keywords

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