Optic Nerve Atrophy Conditions Associated With 3D Unsegmented Optical Coherence Tomography Volumes Using Deep Learning.

Journal: JAMA ophthalmology
Published Date: Aug 21, 2025

Abstract

IMPORTANCE: Accurate differentiation of optic nerve head (ONH) atrophy is vital for guiding diagnosis and treatment of conditions such as glaucoma, nonarteritic anterior ischemic optic neuropathy (NAION), and optic neuritis. Traditional 2-dimensional assessments may overlook subtle, volumetric changes.

Authors

  • David Szanto
    Neurology, Icahn School of Medicine at Mount Sinai, New York, USA.
  • Jui-Kai Wang
    Department of Electrical and Computer Engineering, University of Iowa, Iowa City, IA, USA.
  • Brian Woods
    Irish Clinical Academic Training Programme, Department of Ophthalmology, Cork University Hospital, Cork, Ireland.
  • Asala Erekat
    From the Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, USA (D.S., A.E., M.J.K.).
  • Mona Garvin
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health System, Iowa City, Iowa, USA (M.G., R.K.); Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, USA (M.G.); Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA (M.G., B.A.J., R.K.).
  • Randy Kardon
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health System, Iowa City, Iowa, USA (M.G., R.K.); Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA (M.G., B.A.J., R.K.); University of Iowa Carver College of Medicine, Iowa City, Iowa, USA (R.K.).
  • Mark J Kupersmith
    Departments of Neurology, Neurosurgery and Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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