Integrated multi-omics analysis describes immune profiles in ischemic heart failure and identifies PTN as a novel biomarker.

Journal: Frontiers in molecular biosciences
Published Date: Dec 11, 2024

Abstract

INTRODUCTION: Heart failure is a leading global cause of mortality, with ischemic heart failure (IHF) being a major contributor. IHF is primarily driven by coronary artery disease, and its underlying mechanisms are not fully understood, particularly the role of immune responses and inflammation in cardiac muscle remodeling. This study aims to elucidate the immune landscape of heart failure using multi-omics data to identify biomarkers for preventing cardiac fibrosis and disease progression.

Authors

  • Ting Xiong
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Quhuan Li
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Yifan Wang
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Ying Kong
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Hailin Li
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Jie Liu
    School of Bioscience and Bioengineering, South China University of Technology, Guangzhou, China.
  • Yueheng Wu
    Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.
  • Fengxia Zhang
    Department of Nephrology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

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