Bridging spatial and temporal scales of developmental gene regulation
Journal:
arXiv
Published Date:
Jan 28, 2025
Abstract
The development of multicellular organisms relies on the precise coordination
of molecular events across multiple spatial and temporal scales. Understanding
how information flows from molecular interactions to cellular processes and
tissue organization during development is crucial for explaining the remarkable
reproducibility of complex organisms. This review explores how
chromatin-encoded information is transduced from localized transcriptional
events to global gene expression patterns, highlighting the challenge of
bridging these scales. We discuss recent experimental findings and theoretical
frameworks, emphasizing polymer physics as a tool for describing the
relationship between chromatin structure and dynamics across scales. By
integrating these perspectives, we aim to clarify how gene regulation is
coordinated across levels of biological organization and suggest strategies for
future experimental approaches.
