Ultra-high resolution multimodal MRI dense labelled holistic brain atlas
Journal:
arXiv
Published Date:
Jan 28, 2025
Abstract
In this paper, we introduce holiAtlas, a holistic, multimodal and
high-resolution human brain atlas. This atlas covers different levels of
details of the human brain anatomy, from the organ to the substructure level,
using a new dense labelled protocol generated from the fusion of multiple local
protocols at different scales. This atlas has been constructed averaging images
and segmentations of 75 healthy subjects from the Human Connectome Project
database. Specifically, MR images of T1, T2 and WMn (White Matter nulled)
contrasts at 0.125 $mm^{3}$ resolution that were nonlinearly registered and
averaged using symmetric group-wise normalisation to construct the atlas. At
the finest level, the holiAtlas protocol has 350 different labels derived from
10 different delineation protocols. These labels were grouped at different
scales to provide a holistic view of the brain at different levels in a
coherent and consistent manner. This multiscale and multimodal atlas can be
used for the development of new ultra-high resolution segmentation methods that
can potentially leverage the early detection of neurological disorders.
