Phytochemical profiling and fractionation of extract versus silver nanoparticle-modified extract: assessment of photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties.

Journal: Frontiers in chemistry
Published Date: Dec 10, 2024

Abstract

INTRODUCTION: This study investigates the synthesis of silver nanoparticles (Ag NPs) using Helianthemum lippii extract and evaluates their photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties compared to various extract fractions, including total aqueous extract (AE), flavonoid monoglycosides (FMG), flavonoid diglycosides/triglycosides (FDG/FTG), tannins (TN), and anthocyanins (AC). Helianthemum lippii is rich in bioactive compounds such as caffeic acid, p-coumaric acid, and gallic acid, known for their therapeutic potential. This study aims to determine whether embedding these phytochemicals into Ag NPs enhances their biomedical applications compared to the natural extract fractions.

Authors

  • Ibtissam Laib
    Department of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
  • Djahra Ali Boutlilis
    Department of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
  • Huda Alsaeedi
    Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
  • David Cornu
    Institut Européen des Membranes, IEM, University Montpellier, ENSCM, CNRS, Montpellier, France.
  • Mikhael Bechelany
    Institut Européen des Membranes, IEM, UMR-5635, Univ Montpellier, ENSCM, CNRS, Montpellier, France.
  • Ahmed Barhoum
    NanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.

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