Reproducibility Assessment of Magnetic Resonance Spectroscopy of Pregenual Anterior Cingulate Cortex across Sessions and Vendors via the Cloud Computing Platform CloudBrain-MRS
Journal:
arXiv
Published Date:
Mar 6, 2025
Abstract
Given the need to elucidate the mechanisms underlying illnesses and their
treatment, as well as the lack of harmonization of acquisition and
post-processing protocols among different magnetic resonance system vendors,
this work is to determine if metabolite concentrations obtained from different
sessions, machine models and even different vendors of 3 T scanners can be
highly reproducible and be pooled for diagnostic analysis, which is very
valuable for the research of rare diseases. Participants underwent magnetic
resonance imaging (MRI) scanning once on two separate days within one week (one
session per day, each session including two proton magnetic resonance
spectroscopy (1H-MRS) scans with no more than a 5-minute interval between scans
(no off-bed activity)) on each machine. were analyzed for reliability of
within- and between- sessions using the coefficient of variation (CV) and
intraclass correlation coefficient (ICC), and for reproducibility of across the
machines using correlation coefficient. As for within- and between- session,
all CV values for a group of all the first or second scans of a session, or for
a session were almost below 20%, and most of the ICCs for metabolites range
from moderate (0.4-0.59) to excellent (0.75-1), indicating high data
reliability. When it comes to the reproducibility across the three scanners,
all Pearson correlation coefficients across the three machines approached 1
with most around 0.9, and majority demonstrated statistical significance
(P<0.01). Additionally, the intra-vendor reproducibility was greater than the
inter-vendor ones.
